INCI Name : Madecasosside & Terminoloside (MT)
Nature : Extract (MT-NLT 90%)
Usage Level : 0.1 – 0.5%
Form : White – Cream Colour Powder
Solubility : Soluble in water and other organic solvents
Preservative : None
Advantages : Anti–Ageing, Anti–Inflammatory, Skin Revitaliser, Skin-Smoothening, Skin Repair
If you’re starting to notice age spots, deep wrinkles or a bit of sagging skin on your face, your seeing the effect of structural changes associated with skin damage.
Damaged skin is something all of us experience, but it doesn’t have to stay that way.Madecassoside & Terminoloside(MT), also classed as a triterpenine, stimulates production of type III collagen. While asiaticoside handles the wound-healing side of things, MT separates itself from the pack with its anti-inflammatory properties, making it a popular ingredient for acne-prone skin.
MT has demonstrated some benefit in the treatment of psoriasis, most likely due to its anti-inflammatory properties.The aim of this study was to test the efficacy of C. asiatica extract containing cream versus a placebo cream on 20 volunteers.
Volunteers were selected according to previously agreed inclusion criteria (age 40–70 years). Each volunteer represented their own placebo, applying either the placebo or the test emulsion on each half of the face (randomly selected). The minimal erythemal dose on the forearm was also assessed on 20 volunteers aged 55±9 years. For the anti-wrinkle evaluations, the same volunteers were required to apply the tested emulsion and the placebo emulsion (randomly selected) each on one half of the face for 6 weeks.
Basal measurements as well as final evaluations were carried out at the beginning and at the end of the study. The formulation containing C. asiatica extract at 0.5% was applied, together with the control emulsion, on one side of the faces of 20 volunteers over 6 weeks. Collagen redensification, evaluated by Siascope, was observed in 70% of the tested volunteers (P<0.05), and a significant decrease in wrinkle depth and volume was observed.
The half of the face treated with the centella- containing formulation also showed improved biomechanical elasticity of the skin (evaluated by Cutometer, parameter R5, Figure 1A and 1B) and skin firmness (evaluated by Cutometer parameter R7) by 29% and 17%, respectively (P<0.05) (Figure 1A and 1B).
Reference:
Giada Maramaldi,Stefano Togni, Federico Franceschi,Elian Lati Indena SpA, Milan, Italy; Laboratoire BIO-EC, Longjumeau, France
